Process for preparing indole derivatives containing a...

Details Process for preparing indole derivatives containing a... Process for preparing indole derivatives containing a...

C - Chemistry, Metallurgy

07

D

C07D 403/00 (2006.01) C07D 401/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2140146

A process for preparing tryptamine derivatives and related compounds having a 1,2,4-triazol-1-yl moiety within the molecule comprises reacting 4-amino-1,2,4-triazol with a nitrobenzene derivative containing a readily displaceable group; deaminating the aminotriazolium salt thereby obtained by treatment with nitrous acid followed by neutralisation; reducing the triazolyl-nitrobenzene derivative thereby obtained by transfer hydrogenation; treating the triazolyl-aniline derivative thereby obtained with nitrous acid and then with an alkali metal sulphate, followed by acidification; and subsequently reacting the triazolyl-hydrazine derivative thereby obtained in situ with a suitable carbonyl compound, to obtain the required triazolyl-indole derivative.

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