1-carboxymethyl-2-oxo-azepan derivatives useful as selective...

Details 1-carboxymethyl-2-oxo-azepan derivatives useful as selective... 1-carboxymethyl-2-oxo-azepan derivatives useful as selective...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/55 (2006.01) C07D 223/10 (2006.01)

Patent

CA 2356689

The present invention relates to certain novel 1-carboxymethyl-2-oxo-azepan derivatives of formula (1) useful as inhibitors of matrix metalloproteinases (MMPs). The compounds of formula (1) are especially useful as selective inhibitors of MMP-12. Pharmaceutical compositions containing said compounds as well as methods of treating various disease states responding to inhibition of matrix metalloproteinase are also claimed herein.

Cette invention a trait à certains nouveaux dérivés de 1-carboxyméthyl-2-oxo-azepan, correspondant à la formule (1), utilisés comme inhibiteurs de métalloprotéinases matricielles (MMP). Elle porte également sur des compositions pharmaceutiques renfermant ces composés ainsi que sur des méthodes de traitement de divers états pathologiques réagissant à l'inhibition de la métalloprotéinase matricielle.

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