Pharmacological modulation of positive ampa receptor...

Details Pharmacological modulation of positive ampa receptor... Pharmacological modulation of positive ampa receptor...

A - Human Necessities

61

K

A61K 31/5365 (2006.01) A61K 31/4168 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 45/06 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2649844

Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor (BDNF). The findings described herein suggest a combinatorial approach for drug therapies, using both positive AMPA receptor modulators and mGluR antagonists, to enhance brain neurotrophism.

Selon l'invention, les antagonistes des récepteurs métabotropiques du glutamate (mGluR) du groupe 1 potentialisent l'effet positif des modulateurs des récepteurs AMPA sur l'expression de neurotrophines telles que le facteur neurotrophique dérivé du cerveau (BDNF). Les découvertes décrites dans la présente invention suggèrent pour les thérapies médicamenteuses une approche combinatoire utilisant à la fois des modulateurs positifs des récepteurs AMPA et des antagonistes des récepteurs mGluR pour renforcer le neurotropisme cérébral.

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