C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12N 5/0735 (2010.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 35/48 (2006.01) C07K 14/71 (2006.01)
Patent
CA 2341754
A composition of substantially purified pluripotent stem cells are positive both for fibroblast growth factor receptor (FGFR) and a phenotype indicative of a primitive state, such as CD34+, CD34-lin-, Thy-1+, AC133+ or c-kit+. The state of being an embryonic stem cell is also a phenotype indicative of a primitive state. This population may be further defined by the subpopulations thereof which have another marker thereon indicative of endothelial cells, such a TIE-1+, TEK+, CD31+, VE-Cadherin+ or VEGFR+ or indicative of stromal cells, such as STRO-1+.
Composition de cellules souches pluripotentes sensiblement purifiées présentant un récepteur du facteur de croissance des fibroblastes (FGFR) et un phénotype indiquant un état primitif telles que des cellules souches CD34?+¿, CD34?-¿lin?-¿, Thy-1?+¿, AC133?+¿ ou c-kit?+¿. L'état de cellule souche embryonnaire est également un phénotype qui indique un état primitif. Cette population peut également être définie par des sous-populations de cette dernière portant un autre marqueur qui indique des cellules endothéliales, telles que des cellules TIE-1?+¿, TEK?+¿, CD31?+¿, VE-Cadhérine?+¿ ou VEGFR?+¿ ou qui indique des cellules de stroma, telles que des cellules STRO-1?+¿.
Burger Patricia E.
Wilson E. Lynette
Gowling Lafleur Henderson Llp
New York University
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