Novel polynucleotides encoding lamprey gnrh-iii

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/16 (2006.01) A61K 38/24 (2006.01) C07K 7/23 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2489224

Novel isolated cDNA encoding the precursor of the novel gonadotropin-releasing hormones in four species of the fish lamprey is disclosed. The use of such cDNA s in studying the phylogenetic relationship of various species of fish and vertebrates overall; and the use of such cDNA s for controlling the gonadal development and spawning of fish, including inducing and inhibiting maturation, spawning and reproduction, is also described. Methods by which the novel peptides may be administered to fish to control their reproduction are also described.

L'invention concerne un nouvel ADNc isolé codant le précurseur des hormones de libération des gonadotrophines chez quatre espèces de la lamproie. Ladite invention a également pour objet l'utilisation de cet ADNc dans l'étude du rapport phylogénétique de diverses espèces de poissons et de vertébrés, et l'utilisation de cet ADNc dans la régulation du développement gonadal et de la fraie des poissons, y compris l'induction et l'inhibition de la maturation, de la fraie et de la reproduction. Cette invention a aussi trait à des méthodes au moyen desquelles les nouveaux peptides peuvent être administrés aux poissons afin de réguler leur reproduction.

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