Use of methylated or unmethylated line-1 dna as a cancer marker

Details Use of methylated or unmethylated line-1 dna as a cancer marker Use of methylated or unmethylated line-1 dna as a cancer marker

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2685376

The invention relates to a method of detecting LINE-I (long interspersed nucleotide elenients-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-I DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression and treatment.

La présente invention concerne un procédé de détection d'ADN LINE-I (longs éléments nucléotidiques dispersés 1) methylés ou non methylés au niveau de la région promotrice dans un échantillon de tissu ou de liquide organique prélevé d'un sujet. L'invention concerne également des procédés d'utilisation d'ADN LINE-I comme biomarqueur pour le diagnostic, la prédiction, et le suivi de la progression et du traitement du cancer.

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