Method for identifying inducers and inhibitors of programmed...

Details Method for identifying inducers and inhibitors of programmed... Method for identifying inducers and inhibitors of programmed...

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12Q 1/42 (2006.01)

Patent

CA 2279486

Methods for identifying inducers and inhibitors of programmed cell death in a cell-free system are described. The methods exploit the finding that programmed cell death is accompanied by shutdown of cellular protein synthesis and by phosphorylation of eIF-2.alpha. and that the dephosphorylation of eIF- 2.alpha. prevents the shutdown of protein synthesis.

L'invention concerne des procédés permettant d'identifier les inducteurs et les inhibiteurs de la mort cellulaire programmée dans un système acellulaire. Ces procédés se fondent sur le fait que la mort cellulaire programmée est accompagnée d'une cessation de la synthèse des protéines dans les cellules et par la phosphorylation de eIF-2.alpha., et que la déphosphorylation de eIF-2.alpha. empêche la cessation de la synthèse des protéines.

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