Compstatin analogs with improved activity

Details Compstatin analogs with improved activity Compstatin analogs with improved activity

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2502690

Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. These compounds display improved complement activation-inhibitory activity as compared with currently available compounds. Isolated nucleid acid molecules encoding the peptides are also disclosed.

L'invention concerne des composés comprenant des peptides et des peptidomimétiques capables de se lier à la protéine C3 et d'inhiber une activation de complément. Ces composés présentent une activité d'inhibition-activation de complément par rapport aux composés actuellement disponibles. L'invention concerne également des molécules d'acides nucléiques isolées codant pour lesdits peptides.

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