Foggy

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/00 (2006.01) A61K 35/30 (2006.01) A61K 38/17 (2006.01) A61P 25/00 (2006.01) C07K 14/435 (2006.01) C07K 14/46 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2425980

The present invention relates to neucleotide and amino acid sequences having homology to the zebrafish transcription elongation factor foggy, and to neuronal formation, to a method of directing the differentiation of neuroprogenitor cells into dopaminergic or serotonergic neurons and to a method of treating disorders characterized by abnormalites in and the activity of dopaminergic and serotonergic neurons.

La présente invention concerne des séquences nucléotidiques et des séquences d'acides aminés présentant une homologie avec le facteur foggy d'élongation de transcription du poisson zèbre. L'invention concerne également une formation neuronale ainsi qu'une méthode permettant d'acheminer la différentiation des cellules neuroprogénitrices dans des neurones dopaminergiques ou sérotoninergiques, ainsi qu'une méthode permettant de traiter des troubles caractérisés par des anomalies et par l'activité des neurones dopaminergiques et sérotoninergiques.

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