A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/00 (2006.01) A61L 27/18 (2006.01) A61L 27/36 (2006.01) A61L 33/00 (2006.01) C08G 18/83 (2006.01) C08K 5/5353 (2006.01) C08L 101/02 (2006.01)
Patent
CA 2181721
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or indwelling use in a human or animal body. Illustratively, reaction conditions utilizing bi- or polyfunctional epoxides result in epoxide bridge incorporation of an anticalcification agent and/or an anticoagulant, such as heparin, to the biomaterial elastomer.
L'invention concerne des biomatériaux synthétiques auxquels est fixé un amino diphosphonate, polyphosphonate, ou un autre agent anticalcification afin d'empêcher une calcification in vivo. On peut citer parmi ces biomatériaux des élastomères biocompatibles tels que le polyuréthane et/ou le polydiméthylsiloxane, et analogue, lesquels sont destinés à une utilisation invasive ou à demeure dans le corps d'un animal ou d'un homme. A titre d'exemple, des conditions de réaction utilisant des époxydes bi- ou polyfonctionnels ont pour résultat l'incorporation par pont époxyde d'un agent anticalcification et/ou d'un anticoagulant, tel que l'héparine dans l'élastomère du biomatériau.
Joshi Ravindra R.
Levy Robert J.
Smart & Biggar
The Board Of Regents Acting For And On Behalf Of The University
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