Methods for indentifying markers for early-stage human...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/10 (2006.01) C40B 40/04 (2006.01) C40B 40/08 (2006.01)

Patent

CA 2624213

A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.

La présente invention a trait à un procédé pour l'identification de protéines sécrétées identifiées à des stades de la malignité du cancer. Les protéines sont initialement identifiés par leur capture à l'aide d'une protéine fluorescente contenant un vecteur qui peut s'introduire dans n'importe quel gène. Les protéines sécrétées sont initialement identifiées par leur fluorescence. Des protéines sécrétées identifiant des tumeurs avec des degrés spécifiques de malignité sont isolées en vue de déterminer si elles peuvent être utilisées comme marqueurs de la progression du cancer.

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