Human lung cancer associated gene sequences and polypeptides

A - Human Necessities – 01 – N

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Details

A01N 43/04 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2364629

This invention relates to newly identified lung or lung cancer related polynucleotides and the polypetides encoded by these polynucleotides herein collectively known as "lung cancer antigens", and to the complete gene sequences associated therewith and to the expression products thereof, as well as the use of such lung cancer antigens for detection, prevention and treatment of disorders of the lung, particularly the presence of lung cancer. This invention relates to the lung cancer antigens as well as vectors, host cells, antibodies directed to lung cancer antigens and recombinant and synthetic methods for producing the same. Also provided are diagnostic methods for diagnosing and treating, preventing and/or prognosing disorders related to the lung, including lung cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of lung cancer antigens of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and/or function of the polypetides of the present invention.

Cette invention porte sur des polynucléotides récemment identifiés et associés au cancer du poumon, et sur les polypeptides codés par ces polynucléotides et connus collectivement sous le nom <= d'antigènes du cancer du poumon>=. L'invention porte également sur les séquences géniques complètes associées et sur leurs produits d'expression, ainsi que sur l'utilisation de ces antigènes du cancer du poumon dans la détection, la prévention et le traitement des pathologies du poumon telles que le cancer. Cette invention porte sur les antigènes du cancer du poumon, ainsi que sur les vecteurs, les cellules hôtes, les anticorps dirigés contre les antigènes du cancer du poumon et sur des procédés recombinants et synthétiques de production de ces anticorps. L'invention porte également sur des procédés de diagnostic permettant de diagnostiquer et traiter, prévenir et/ou établir un pronostic de pathologies du poumon telles que le cancer, et sur des procédés thérapeutiques visant à traiter ces pathologies. Cette invention porte en outre sur des procédés de recherche automatique visant à identifier des agonistes et des antagonistes des antigènes du cancer du poumon, et sur des procédés et/ou des compositions visant à inhiber la production et/ou la fonction des polypeptides de cette invention.

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