Polyethylene glycol derivatives, process for preparing the...

Details Polyethylene glycol derivatives, process for preparing the... Polyethylene glycol derivatives, process for preparing the...

C - Chemistry, Metallurgy

12

N

530/15, 195/33.1

C12N 11/08 (2006.01) A61K 47/48 (2006.01) C07D 251/26 (2006.01) C07K 1/107 (2006.01) C07K 17/08 (2006.01) C08G 65/32 (2006.01) C08G 65/329 (2006.01) C08G 65/333 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2017543

ABSTRACT OF THE DISCLOSURE High purity polyethylene glycol derivatives of formula (I) are useful as protein modifiers of inter- ferons, t-PA, EGF, various hormones, etc. The thus modified protein has minimized antigenicity, prolonged plasma half life, or improved transfer to tissue. A novel process for preparing high purity polyethylene glycol derivatives is also disclosed.

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