Method to treat rheumatoid arthritis

Details Method to treat rheumatoid arthritis Method to treat rheumatoid arthritis

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/13 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 14/74 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2056450

2056450 9014835 PCTABS00002 Subjects may be immunized against rheumatoid arthritis by administering the peptide Q(K/R)RAA in immunogenic form in a protocol leading to preferential expansion of suppressor and/or cytotoxic T-cells rather than helper T-cells. This preferential expansion can be effected by administration of interleukin-6 and/or cyclosporin A. Alternatively, the Q(K/R)RAA peptide coupled to the invariant region of a Class I histocompatibility sequence may be administered. Also disclosed are pharmaceutical compositions useful in the vaccination protocols.

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