Use of a peptide as a therapeutic agent

Details Use of a peptide as a therapeutic agent Use of a peptide as a therapeutic agent

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/08 (2006.01) A61K 38/12 (2006.01) A61P 1/00 (2006.01) A61P 1/02 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 31/00 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2698980

The present invention is directed to the use of the peptide compound Pyr-Gly- Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu- Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pyr-Gly-Pro-Trp- Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

La présente invention concerne l'utilisation d'un composé peptidique Pyr-Gly-Pro-Trp- Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 en tant qu'agent thérapeutique pour la prophylaxie et/ou le traitement des pathologies suivantes: cancer, maladies auto-immunes, maladies neurodégénératives, maladies infectieuses, affections cardiaques, maladies cardio-vasculaires et troubles du métabolisme. De plus, cette invention concerne des compositions pharmaceutiques, de préférence sous forme d'un lyophilisat, d'une solution tampon liquide, d'une préparation de lait maternel artificiel ou d'un substitut de lait maternel contenant le peptide Pyr-Gly-Pro-Trp- Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2, éventuellement avec au moins un véhicule de qualité pharmaceutique, un agent cryoprotecteur, un agent lyoprotecteur, un excipient et/ou un diluant.

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