A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 33/24 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2750147
The present invention relates to an anticancer composition comprising an antitumor agent as well as a substance having inhibitory effects on the activity or expression of L1CAM; more particularly, to an anticancer composition, which comprises an anti-L1CAM antibody specific to L1CAM, serving as a substance for inhibiting the activity of L1CAM; an oligonucleotide inhibiting the generation of L1CAM, serving as a substance for inhibiting the expression of L1CAM; and a substance selected from cisplatin, gemcitabine, 5-fluorouracil and taxol, serving as an antitumor agent. The composition according to the present invention has the benefit of the combined use of a substance having inhibitory effects on the activity or an expression of L1CAM and an antitumor agent concurrently, separately or sequentially so that it demonstrates stronger and more significant pharmaceutical effects than the exclusive use of those substances on inhibiting proliferation and inducing apoptosis in cancer cells, thereby making it very useful for cancer treatment.
L'invention concerne une composition anticancéreuse comprenant une substance et un agent antitumoraux et présentant des effets inhibiteurs sur l'activité et l'expression de L1CAM, et en particulier, une composition anticancéreuse qui comprend un anticorps anti-L1CAM, spécifique de L1CAM, servant de substance d'inhibition de l'activité de L1CAM: un oligonucléotide inhibant la génération de L1CAM, servant de substance d'inhibition de l'expression de L1CAM; et une substance sélectionnée parmi: le cisplatine, la gemcitabine, le 5-fluoro-uracile et le taxol, servant d'agent antitumoral. La composition selon l'invention présente l'avantage de combiner l'utilisation d'une substance présentant des effets inhibiteurs sur l'activité ou l'expression of L1CAM à l'utilisation d'un agent antitumoral, de manière simultanée, séparée ou séquentielle. Ainsi, l'invention présente des effets pharmaceutiques plus forts et plus importants que ceux obtenus par l'utilisation exclusive de ces substances pour inhiber la prolifération et pour induire l'apoptose de cellules cancéreuses, ce qui rend l'invention très utile pour un traitement anticancéreux.
Hong Hyo Jeong
Lee Jung Whoi
Min Jeong-Ki
Yoon Hyunho
Goudreau Gage Dubuc
Korea Research Institute Of Bioscience And Biotechnology
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