C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2442816
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating hematopoietic and hematologic diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
La présente invention concerne des polypeptides sécrétés par l'homme, ainsi que des molécules d'acide nucléique isolées codant ces polypeptides, et convenant pour le diagnostic et le traitement de troubles et affections hématologiques et hématopoïétiques, et/ou des états s'y rapportant. L'invention concerne également des anticorps qui se lient à ces polypeptides, ainsi que des vecteurs des cellules hôtes et des procédés de recombinaison et de synthèse permettant de produire ces polynucléotides, polypeptides et/ou anticorps. L'invention concerne aussi des procédés de recherche systématique permettant d'identifier des agonistes et des antagonistes des polynucléotides et polypeptides de l'invention. L'invention concerne enfin Des procédés et composition permettant de bloquer ou de renforcer la production et les fonctions des polypeptides de l'invention.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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