C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/24 (2006.01) A61K 31/472 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 37/00 (2006.01) C07D 493/08 (2006.01) C07D 495/08 (2006.01)
Patent
CA 2728123
The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
La présente invention concerne des derivés bicycliques et polycycliques disoquinoline et disoquinolinone substitués de formule (I) dans laquelle : R1 à R12 sont tels que définis dans la description, utiles pour le traitement et/ou la prévention de maladies associées à la Rho-kinase et/ou à la phosphorylation médiée par la Rho-kinase de la phosphatase à chaîne légère de myosine, ainsi que des compositions contenant de tels composés.
Biscarrat Sandrine
Duclos Olivier
Loehn Matthias
Lorenz Katrin
Plettenburg Oliver
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis
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