Microarray fabrication techniques and apparatus

B - Operations – Transporting – 01 – J

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Details

B01J 19/00 (2006.01) B01L 3/00 (2006.01) B01L 3/02 (2006.01) G01N 21/25 (2006.01) G01N 21/64 (2006.01) B81B 1/00 (2006.01) G01N 35/10 (2006.01)

Patent

CA 2399189

Disclosed is a microarray printing system and methods of printing probe microarrays 1000. The system has a print-head (102, 606, 706, 806) formed of one or more capillary bundle (104), such as light-guiding capillaries. The bundles (104) may especially be bundles (104) of capillaries that provide a large number of probes 1004 on the surface of a substrate. Methods of registering or correlating the distal 112 and proximal 110 ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays 1000 that are missing one or more probes from the surface of the microarray 1000.

L'invention concerne un système d'impression pour jeu ordonné de microéchantillons et des procédés d'impression pour jeu ordonné de microéchantillons à sondes. Le système comporte une tête d'impression constituée d'un ou plusieurs faisceaux de capillaires (par exemple, capillaires à guidage optique de la lumière). En particulier, les faisceaux peuvent être des faisceaux de capillaires permettant d'établir un grand nombre de sondes à la surface d'un substrat. L'invention concerne également des procédés d'enregistrement ou de corrélation des extrémités distale et proximale des capillaires. L'invention concerne enfin des procédés et des équipements permettant d'identifier les jeux ordonnés défectueux à la surface desquels il manque une ou plusieurs sondes.

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