Compositions comprising atorvastatin 4-(nitrooxy) butyl...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01)

Patent

CA 2724873

The present invention relates to compositions comprising atorvastatin 4- (nitrooxy) butyl ester and a hypolipidemic, in particular ezetimibe and fenofibrate. The invention discloses also their use as cholesterol-reducing drugs, as drugs having immunosuppressive properties, antioxidant, antithrombotic and anti- inflammatory activity, effects on endothelial function, and for treating and/or preventing acute coronary syndromes, stroke, atherosclerosis, neurodegenerative disorders, such as Alzheimer's and Parkinson's disease as well as autoimmune diseases, such as multiple sclerosis.

La présente invention porte sur des compositions comprenant de l'ester 4-(nitrooxy)butylique d'atorvastatine et un médicament hypolipidémique, en particulier l'ézétimibe et le fénofibrate. L'invention porte également sur leur utilisation en tant que médicaments réduisant le cholestérol, en tant que médicaments ayant des propriétés immunosuppressives, une activité anti-oxydante, antithrombotique et anti-inflammatoire, des effets sur la fonction endothéliale et pour traiter et/ou prévenir des syndromes coronaires aigus, un accident vasculaire cérébral, une athérosclérose, des troubles neurodégénératifs, tels que la maladie d'Alzheimer et la maladie de Parkinson ainsi que des maladies auto-immunes, telles que la sclérose en plaques.

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