C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/4995 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2632642
This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
La présente invention concerne des dérivés innovants d'aryle diazabicyclique qui se sont avérés être des ligands cholinergiques au niveau des récepteurs de l'acétylcholine nicotinique et des modulateurs des récepteurs et des transporteurs de monoamine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utiles pour le traitement de maladies ou de troubles aussi divers que ceux liés au système cholinergique du système nerveux central (SNC) ou au système nerveux périphérique (SNP), les maladies ou les troubles liés à la contraction des muscles lisses, les maladies ou les troubles endocriniens, les maladies ou les troubles liés à la dégénérescence du système nerveux, les maladies ou les troubles liés à l'inflammation, à la douleur et aux symptômes de sevrage causés par l'arrêt de l'abus de substances chimiques.
Dyhring Tino
Nielsen Elsebet Oestergaard
Olsen Gunnar M.
Peters Dan
Timmermann Daniel B.
Mccarthy Tetrault Llp
Neurosearch A/s
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