Eb1 gene product binds to apc

Details Eb1 gene product binds to apc Eb1 gene product binds to apc

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2221159

Inactivation of the APC tumor suppressor gene plays an important role in the development of both sporadic and familial forms of colorectal cancers. The majority of these mutations result in the loss of the carboxyl terminus of the APC protein. A cellular protein, EB1, that associates with the carboxyl terminus of APC both in vitro and in vivo has been identified. The EB1 gene is predicted to encode a 268 amino acid protein without significant homology to any protein with known function.

L'inactivation du gène suppresseur de la tumeur APC (polypose rétro-colique familiale) joue un rôle important dans le développement des cancers colo-rectaux de type familial et sporadique. La majorité de ces mutations est due à la perte de l'extrémité carboxyle de la protéine APC. Une protéine cellulaire, EB1, qui s'associe à l'extrémité carboxyle de l'APC, tant in vitro que in vivo, a été identifiée. Le gène EB1 code une protéine d'acide aminé 268 sans homologie notable avec toute protéine présentant une fonction connue.

Affiliated with

Also associated with

Rating

Eb1 gene product binds to apc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Eb1 gene product binds to apc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Eb1 gene product binds to apc will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1645194