Medicament for inhibiting nf-kb

Details Medicament for inhibiting nf-kb Medicament for inhibiting nf-kb

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2369448

Compounds of formula (I) (see formula I) wherein R1 through R8 are selected independently from hydrogen atoms and pharmaceutically acceptable substituents, as well as pharmaceutically acceptable salts of compounds of formula (I) and mixtures of substances containing at least one compound of formula (I) or a pharmaceutically acceptable salt thereof are used for preparation of medicaments for inhibiting transcription factor NF-.kappa.B and/or for inhibiting COX with a preferential inhibitory effect for COX-2.

L'invention concerne des composés de la formule (I) dans laquelle R<1> à R<8> compris sont sélectionnés indépendamment les uns des autres parmi les atomes d'hydrogène et des substituants pharmaceutiquement acceptables, ainsi que des sels acceptables des composés de la formule (I) et des mélanges de substances qui contiennent au moins un composé de la formule (I) ou son sel pharmaceutiquement acceptable. Ces composés s'utilisent pour préparer des médicaments permettant d'inhiber le facteur de transmission NF- kappa B et/ou d'inhiber le COX avec un effet inhibiteur préférentiel pour le COX-2 et/ou d'inhiber la libération d'histamine et/ou de sérotonine.

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