N-linked sulfonamides of heterocyclic thioesters

Details N-linked sulfonamides of heterocyclic thioesters N-linked sulfonamides of heterocyclic thioesters

C - Chemistry, Metallurgy

07

D

C07D 207/48 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 31/18 (2006.01) A61P 43/00 (2006.01) C07D 207/46 (2006.01) C07D 211/96 (2006.01) C07D 215/58 (2006.01) C07D 217/12 (2006.01) C07D 223/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2

Patent

CA 2239926

This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

L'invention a trait à des sulfonamides neurotrophiques de thioesters hétérocycliques, de faible poids moléculaire, qui sont formés de petites molécules liées par l'azote et qui ont une affinité pour les immunophilines de type FKBP, ainsi qu'à leur utilisation comme inhibiteurs de l'activité enzymatique associée aux immunophilines, en particulier de l'activité de la peptidyl-prolyl isomérase, ou de la rotamase.

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