Solubilized thiazolopyridines

Details Solubilized thiazolopyridines Solubilized thiazolopyridines

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2705138

Provided herein are novel sirtuin-modulating compounds Structural Formula (I): and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L'invention porte de nouveaux composés de modulation des sirtuines de formule structurale (I) : et sur des procédés d'utilisation de ces composés. Les composés de modulation des sirtuines peuvent être utilisés pour augmenter la durée de vie d'une cellule et pour traiter et/ou prévenir une large diversité de maladies et troubles comprenant, par exemple, les maladies ou troubles se rapportant au vieillissement ou au stress, le diabète, l'obésité, les maladies neurodégénératives, une maladie cardiovasculaire, les troubles de la coagulation du sang, une inflammation, le cancer et/ou les bouffées vasomotrices, ainsi que les maladies ou troubles qui bénéficieraient d'une activité mitochondriale accrue. L'invention porte également sur des compositions comprenant un composé de modulation des sirtuines en combinaison avec un autre agent thérapeutique.

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