A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/00 (2006.01) A61K 31/4741 (2006.01) A61K 38/00 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2349720
The present invention provides a methodology and compositions for stimulating angiogenesis in-situ within viable cells, tissues and organs comprising endothelial cells. The methodology focuses upon and controls the phosphorylation of the 183rd amino acid residue, serine within the cytoplasmic domain and intracellular tail of transmembrane syndecan-4 proteoglycans which are then positioned at and through the cellular membrane of viable endothelial cells. By intervening and maintaining the 183rd residue in a non- phosphorylated state, a consequential cascade of intracellular events is initiated which result in a stimulation of angiogenesis in-situ.
La présente invention se rapporte à une méthode et à des compositions permettant de stimuler in situ l'angiogenèse de cellules viables, de tissus et d'organes comportant des cellules endothéliales. Cette méthode est axée sur la phosphorylation et la régulation de la phosphorylation du 183?eme¿ reste d'acide aminé, la sérine, au sein du domaine cytoplasmique et de la queue intracellulaire des protéoglycanes syndecane-4 transmembranaires qui sont alors positionnés sur et dans la membrane cellulaire des cellules endothéliales viables. Le fait d'intervenir et de maintenir le 183?eme¿ reste dans un état non-phosphorylé, permet d'amorcer une cascade d'événements intracellulaires qui provoque une stimulation in situ de l'angiogenèse.
Horowitz Arie
Simons Michael
Beth Israel Deaconess Medical Center
Smart & Biggar
LandOfFree
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