C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C12N 15/00 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C07K 14/805 (2006.01)
Patent
CA 2652894
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and related translation systems.
La présente invention concerne des paires orthogonales d'ARNt et d'aminoacyle ARNt synthétases incorporant l'acide aminé L-(7-hydroxycoumarin-4-yl) éthylglycine non naturel de coumarine dans des protéines produites dans des cellules hôtes eubactériennes telles que E.coli. L'invention concerne, par exemple, entre autres, de nouvelles synthétases orthogonales, des procédés d'identification et de fabrication de nouvelles synthétases, des procédés de production de protéines contenant l'acide aminé L-(7-hydroxycoumarin-4-yl) éthylglycine non naturel de coumarine et des systèmes de traduction associés.
Schultz Peter G.
Wang Jiangyun
Xie Jianming
Fetherstonhaugh & Co.
The Scripps Research Institute
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