C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/14 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2672815
The present invention relates to a compound of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1,R2, R3, R4, R5, A, X, n, and are as defined herein. Such novel benzamidazole derivatives are useful in trv treatment of abnormal cell growth, such as cancer, in mammals. This invention ate relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing sue compounds.
L'invention porte sur un composé de formule (I) ou l'un de ses sel pharmaceutiquement acceptable dans laquelle: R1, R2, R3, R4, R5, A, X, n sont tels que définis dans la description. Ces nouveaux dérivés du benzamidazole s'avèrent utiles dans le traitement de la croissance cellulaire anormale, telle que le cancer, chez les mammifères. L'invention porte également sur une méthode d'utilisation desdits composés pour le traitement de la croissance cellulaire anormale chez les mammifères, particulièrement les humains, et sur des préparations pharmaceutiques les contenant.
Jones Christopher Scott
Li Qifang
Linde Robert Gerald II
Munchhof Michael John
Reiter Lawrence Alan
Pfizer Products Inc.
Torys Llp
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