C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/635 (2006.01) A61K 38/00 (2006.01) A61K 38/29 (2006.01) A61K 47/48 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2096933
Carboxyl terminal fragments of PTHcP also known by the name adenylate cyclase stimulating factor [ACSF] and bone rel- easing factor [BRF] are shown to possess bone resorption inhibitory activity which is an opposite activity to that embodied by the complete PTHrP sequence and N-terminal fragments thereof. There is described compounds having bone resorption Inhibitory activity which comprise carboxy terminal fragment of PTHrP consisting of at least amino acids 107-111 of PTHrP, or a derivative thereof. Methods for the inhibition of bone resorption, and methods for the treatment of diseases characterised by excess bone resorption are also described, which methods comprise administering to a subject in need of such treatment a bone resorption in- hibitory effective amount of a carboxy terminal fragment of PTHrP consisting of at least amino acids 107-111 of PTHrP or a de- rivative thereof optionally in association with a pharmaceutically acceptable carrier or excipient.
Fenton Anna J.
Hammonds R. Glenn
Kemp Bruce E.
Martin Thomas J.
Nicholson Geoffrey C.
Fetherstonhaugh & Co.
Genentech Inc.
The University Of Melbourne
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