C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/10 (2006.01) A61K 9/127 (2006.01) A61K 31/685 (2006.01) A61K 48/00 (2006.01) A61P 33/02 (2006.01) C07C 51/09 (2006.01) C07F 9/113 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2339495
The invention relates to the production of phospholipids with synthetic, unsaturated alkyl and acyl chains according to general formula (I) A - PO3 - B, wherein B represents a radical of general formula (II), wherein n is a whole number from 2 to 8; m is 0, 1 or 2; x is a whole number from 0 to 8; y is a whole number from 1 to 4; z is a whole number from 0 to 5; R3 represents an alkyl radical with 1 to 3 C atoms that may be substituted by one or more hydroxyl groups and wherein A represents a radical selected from one of the formulae (III) to (IX). Said compounds are suitable as liposome components, active substances and solutizing agents.
L'invention concerne des phospholipides renfermant des chaînes alkyle et acyle insaturées synthétiques, de formule générale (I) A-PO3-B. Dans cette formule, B représente un résidu de formule générale (II), dans laquelle n est un entier compris entre 2 et 8 ; m est 0, 1 ou 2 ; x est un entier compris entre 0 et 8 ; y est un entier compris entre 1 et 4 ; z est un entier compris entre 0 et 5 ; R3 est un résidu alkyle renfermant 1 à 3 atomes de carbone, qui peut être substitué par un ou plusieurs groupes hydroxyle; et A représente un résidu choisi entre les formules (III) à (IX). Ces composés peuvent être utilisés comme composants de liposomes, substances actives ou agents de solubilisation.
Eibl Hansjorg
Hottkowitz Thomas
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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