Mesoderm and definitive endoderm cell populations

Details Mesoderm and definitive endoderm cell populations Mesoderm and definitive endoderm cell populations

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/0735 (2010.01) A61K 35/407 (2006.01) C12Q 1/02 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2613387

The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.

L'invention concerne des populations cellulaires enrichies en cellules mésendodermiques et mésodermiques, et des populations cellulaires enrichies en cellules endodermiques. Les populations cellulaires de l'invention sont utiles pour générer des cellules et pour la thérapie de substitution de cellules. L'invention concerne en outre une méthode de génération d'hépatocytes, de populations cellulaires enrichies en hépatocytes, et une méthode thérapeutique de substitution d'hépatocytes.

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