Fringe proteins and notch signalling

Details Fringe proteins and notch signalling Fringe proteins and notch signalling

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2268751

Three mammalian Fringe cDNAs have been cloned and sequenced, and their interaction with the Notch receptor signalling pathway has been described. Methods are provided for preventing or treating disorders characterised by an abnormality in Notch receptor signalling.

On a cloné et séquencé trois ADNc frangés de mammifère; on a décrit leur interaction avec la voie de signalisation du récepteur de Notch. L'invention propose des méthodes de prévention et de traitement de troubles caractérisés par une anomalie de signalisation du récepteur de Notch.

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