C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/437 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2536544
The present invention discloses compounds of formula (I) wherein Ar, X, R1 and R 11 are herein defined, said compounds being novel antagonists for melanin- concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
L'invention concerne des composés représentés par la formule (I), Ar, X, R?1 ¿et R ?11 ¿étant définis dans le descriptif. Ces composés sont de nouveaux antagonistes de l'hormone concentrant la mélanine (MCH). L'invention concerne également des procédés permettant de préparer ces composés. Dans une forme de réalisation différente, l'invention concerne des compositions pharmaceutiques contenant ces antagonistes de MCH ainsi que des méthodes d'utilisation de ces compositions pour le traitement de l'obésité, des troubles métaboliques, et des trouble de l'alimentation, tels que l'hyperphagie et le diabète par exemple.
Burnett Duane A.
Caplen Mary Ann
Wu Wen-Lian
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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