Taci-immunoglobulin fusion proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2448123

Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand- interactor (TACI) receptors.

Les molécules qui interfèrent avec la liaison d'un récepteur du facteur de nécrose des tumeurs avec son ligand, par exemple un récepteur soluble présentent une utilité confirmée tant pour la recherche fondamentale qu'en tant qu'agents thérapeutiques. L'invention concerne des récepteurs solubles améliorés à activation transmembranaire et à interaction avec les modulateurs du calcium et le ligand de la cyclophiline (TACI).

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