Fluorescence polarization imaging devices and methods

Details Fluorescence polarization imaging devices and methods Fluorescence polarization imaging devices and methods

G - Physics

01

N

G01N 21/64 (2006.01) A61B 5/00 (2006.01) A61B 6/00 (2006.01) G01N 21/21 (2006.01)

Patent

CA 2539184

The present invention is directed to a novel multi-spectral exogenous fluorescence polarization imaging technique that enables rapid imaging of large tissue fields. The imaging device includes a tunable monochromatic light source and a CCD camera. Linear polarizers are placed into both the incident and collected light pathways in order to obtain fluorescence polarization or/and anisotropy image. To acquire exogenous fluorescence image, fluorescent contrast agents are delivered to a target tissue.

L'invention concerne une nouvelle technique d'imagerie par polarisation de fluorescence exogène multispectrale permettant d'imager rapidement de vastes champs tissulaires. Le dispositif d'imagerie selon l'invention comprend une source de lumière monochromatique accordable et une caméra à dispositif de couplage de charge (CCD). Des polariseurs linéaires sont placés à la fois dans le trajet de lumière incidente et dans le trajet de lumière recueillie, de sorte à obtenir une image de polarisation de fluorescence et/ou d'anisotropie. Afin d'acquérir une image de fluorescence exogène, des produits de contraste fluorescents sont libérés dans le tissu cible.

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