Biological tissue growth through induced tensile stress

A - Human Necessities – 61 – B

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A61B 17/00 (2006.01) C12N 5/071 (2010.01) C12N 5/077 (2010.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61P 41/00 (2006.01) C12M 3/00 (2006.01)

Patent

CA 2688525

A tissue expansion device implanted in a non-activated state over a region of desired tissue growth. Once implanted and positioned the device is activated creating a supporting structure that creates a convex shaped dome over the underlying tissue. The convex shaped dome formed by the tissue expansion device places a tensile stress against the underlying tissue that promotes tissue growth. Alone or with the introduction of tissue enhancing agents and/or adipose tissue, new tissue within the convex shaped void grows until a balance is achieved eliminating the induced stress. Periodically the tissue expansion devices is again activated and enlarged creating an even larger void. Again, the newly enlarged void places additional tensile stress on the underlying tissue thus repeating the cycle of new tissue growth. Once the desired amount of tissue growth has been achieved the device is deactivated and removed.

L'invention concerne un dispositif de dilatation de tissu implanté dans un état non activé sur une région de croissance de tissu souhaitée. Une fois implanté et positionné, le dispositif est activé, créant une structure de support qui crée un dôme de forme convexe sur le tissu sous-jacent. Le dôme de forme convexe formé par le dispositif de dilatation de tissu place une contrainte de tension sur le tissu sous-jacent, ce qui favorise la croissance de tissu. Seuls ou avec l'introduction d'agents améliorant les tissus et/ou le tissu adipeux, de nouveaux tissus dans le vide de forme convexe poussent jusqu'à atteindre un équilibre éliminant la contrainte induite. Périodiquement, le dispositif de dilatation de tissu est à nouveau activé et agrandi, créant un vide encore plus grand. A nouveau, le vide nouvellement agrandi place une contrainte de tension supplémentaire sur le tissu sous-jacent, répétant ainsi le cycle de croissance de nouveaux tissus. Une fois que la quantité souhaitée de croissance de tissu a été atteinte, le dispositif est désactivé et retiré.

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