Reagent for endotoxin-specific assay

Details Reagent for endotoxin-specific assay Reagent for endotoxin-specific assay

G - Physics

01

N

G01N 33/579 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2133190

ABSTRACT OF THE DISCLOSURE Endotoxin (Et) can be specifically assayed by exclusively utilizing the factor C system reaction without being affected by factor G contained in a limulus amebocyte lysate reagent. The present invention provides: (1) a reagent for ET- specific assay which comprises a limulus amebocyte lysate reagent and an alkylglucoside; (2) a method of specifically assaying Et in a specimen using a limulus amebocyte lysate reagent, wherein an alkylglucoside is added to the limulus amebocyte lysate reagent and/or the specimen; and (3) a factor G activation inhibitor composition which comprises an alkylglucoside as an active ingredient capable of inhibiting the activation of factor G in limulus amebocyte by (1?3)-.beta.-D- glucan.

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