Cellular internalization of pigr stalk and associated ligands

Details Cellular internalization of pigr stalk and associated ligands Cellular internalization of pigr stalk and associated ligands

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/02 (2006.01) C07K 16/46 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2256304

Compositions and methods for specific binding to the stalk of a polymeric immunoglobulin receptor (pIgR) of a cell with the proviso that the ligand does not substantially bind to secretory component of pIgR under physiological conditions. The ligand may be targeted to, into, or across the cell and may comprise a biologically active composition.

L'invention concerne des compositions et des procédés pour la fixation spécifique à la tige d'un récepteur d'immunoglobuline polymère (pIgR) d'une cellule, le ligand ne devant sensiblement pas se fixer au composant sécrétoire du pIgR dans des conditions physiologiques. Le ligand peut être destiné à se fixer sur la cellule, dans la cellule, ou à traverser celle-ci et peut comprendre une composition biologiquement active.

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