Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl)...

Details Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl)... Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl)...

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01)

Patent

CA 2313230

The present invention relates to a thermodynamically stable modification of the active compound ramatroban of formula (I). The thermodynamically stable form is prepared either by melting of the metastable form and subsequent recrystallization or by seeding a solution of the metastable active compound with a seed crystal of the thermodynamically stable form. The thermodynamically stable active compound can be employed as an asthma agent.

La présente invention concerne une modification thermodynamiquement stable du composant actif ramatrobane de la formule (I). On prépare cette forme thermodynamiquement stable soit en faisant fondre la forme métastable, puis en la recristallisant, soit en ensemençant une solution du composé actif métastable avec un germe cristallin de la forme thermodynamiquement stable. Le composé actif thermodynamiquement stable peut servir d'agent antiasthmatique.

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