Thrombin derived peptides for promoting cardiac tissue repair

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/48 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 33/16 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2511223

The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascaular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.

L'invention concerne une méthode pour favoriser la réparation du tissu cardiaque, cette méthode consistant à administrer au tissu cardiaque une quantité thérapeutiquement efficace d'un peptide angiogénique dérivé de la thrombine et/ou à inhiber ou à réduire l'occlusion vasculaire ou la resténose. La présente invention porte également sur des méthodes pour stimuler la revascularisation, ainsi que sur l'utilisation de peptides dérivés de la thrombine dans la préparation d'un médicament utilisé dans les méthodes qui font l'objet de l'invention.

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