A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C07K 16/10 (2006.01) C07K 16/18 (2006.01) C12N 15/13 (2006.01) G01N 33/15 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2757333
The present invention relates, in general, to animal models suitable for testing candidate immunogens and, in particular, to knock-in mice expressing heavy and light chains of membrane proximal external region (MPER) HIV-I broadly neutralizing antibodies and to methods of screening candidate immunogens using same.
La présente invention porte, d'une manière générale, sur des modèles animaux appropriés pour tester des immunogènes candidats et, en particulier, sur des souris knock-in exprimant des chaînes lourdes et légères d'anticorps neutralisant largement le VIH-I de région externe proximale de membrane (MPER) et sur des procédés de criblage d'immunogènes candidats les utilisant.
Haynes Barton F.
Verkoczy Laurent K.
Duke University
Goudreau Gage Dubuc
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