Thiazolidine derivatives with anti-diabetic activity, their...

Details Thiazolidine derivatives with anti-diabetic activity, their... Thiazolidine derivatives with anti-diabetic activity, their...

C - Chemistry, Metallurgy

07

D

167/234, 260/310

C07D 277/34 (2006.01) A61K 31/425 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2035832

Compounds of formula (I): (see formula I) [in which: A is a group of formula (II) or (III): (see formula II or III) W is methylene, carbonyl or >C=N-OV, where V is hydrogen, sulpho, acyl or alkyl; U is methylene, or W is absent and U is a carbon-carbon double bond between A and -CR1(OH)-; R1, R2, R3 and R4 are each hydrogen or alkyl; Y1 and Y2 are each hydrogen or a hydroxy-protecting group; and n is 1, 2 or 3] and salts thereof have anti-diabetic activity in mammals. Methods of preparing them are also provided.

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