Benzoxazole derivatives and their use as adenosine receptor...

Details Benzoxazole derivatives and their use as adenosine receptor... Benzoxazole derivatives and their use as adenosine receptor...

C - Chemistry, Metallurgy

07

D

C07D 263/58 (2006.01) A61K 31/423 (2006.01) A61K 31/4439 (2006.01) A61P 25/28 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2512602

The invention relates to compounds of formula (I), wherein R is phenyl, unsubstituted or substituted by halogen or -CH2N(CH3)(CH2)nOCH3, or is benzyl, lower alkyl, lower alkoxy, -(CH2)nOCH3, or is pyridin 3-or 4-yl, unsubstituted or substituted by lower alkyl, halogen, morpholinyl, -(CH2)n-halogen, - (CH2)nOCH3 -(CH2)n-morpholin-4-yl, or -(CH2)npyrrolidin-1-yl; R1 is phenyl, unsubstituted or substituted by halogen, tetrahydropyran-4-yl, 3,6-dihydro-2H- pyran-4-yl or morpholin-4-yl; n is independently from each other 1 or 2; and to pharmaceutically acceptable acid addition salts thereof for the treatment of diseases related to the adenosine A2A-receptor.

L'invention concerne des composés de formule (I), dans laquelle R représente un groupe phényle, non substitué ou substitué par des halogènes ou par -CH¿2?N(CH¿3?)(CH¿2?)¿n?OCH¿3?, ou représente un groupe benzyle, alkyle inférieur, alcoxy inférieur ou -(CH¿2?)¿n?OCH¿3? ou représente un groupe pyridine-3-yle ou pyridine-4-yle, non substitué ou substitué par un groupe alkyle inférieur, des halogènes, un groupe morpholinyle, -(CH¿2?)¿n?-halogène, -(CH¿2?)¿n?OCH¿3?, -(CH¿2?)¿n?-morpholine-4-yle ou -(CH¿2?)¿n?-pyrrolidine-1-yle et R?1¿ représente un groupe phényle, non substitué ou substitué par des halogènes, un groupe tétrahydropyrane-4-yle, 3,6-dihydro-2H-pyrane-4-yle ou morpholine-4-yle, n représentant indépendamment 1 ou 2, ainsi que des sels d'addition d'acide pharmaceutiquement acceptables de ces composés destinés au traitement de maladies liées au récepteur de l'adénosine A¿2A?.

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