Aza-amino acid derivatives (factor xa-inhibitors 15)

Details Aza-amino acid derivatives (factor xa-inhibitors 15) Aza-amino acid derivatives (factor xa-inhibitors 15)

C - Chemistry, Metallurgy

07

C

C07C 311/47 (2006.01) A61K 31/175 (2006.01) A61K 31/18 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07C 317/42 (2006.01) C07C 333/04 (2006.01) C07D 211/46 (2006.01) C07D 213/30 (2006.01) C07D 257/04 (2006.01) C07D 295/08 (2006.01) C07D 295/088 (2006.01) C07D 317/40 (2006.01)

Patent

CA 2415838

The invention relates to semicarbicides of the general formula (I), wherein R1, R2, R3, R4 and I are defined as in claim 1. The compounds of formula (I) can be used as active ingredients for medicaments in human and veterinary medicine, especially for combating and preventing thromboembolic diseases such as thrombosis, myocardial infarction, arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis after angioplasty, intermittent claudication, tumors, tumor diseases and/or tumor metastases.

Semicarbazides de formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et I possèdent la signification figurant dans la revendication 1. Les composés de formule I peuvent être utilisés comme principes actifs dans la médecine humaine et vétérinaire, en particulier pour lutter contre les maladies thromboemboliques tels que la thrombose, l'infarctus du myocarde, l'artériosclérose, les inflammations, l'apoplexie, l'angine de poitrine, la resténose après angioplastie, la claudication intermittente, les tumeurs, les maladies tumorales et / ou les métastases tumorales, et prévenir ces maladies.

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