Novel 2-amino-imidazo[4,5-d]pyridazin-4-ones and...

Details Novel 2-amino-imidazo[4,5-d]pyridazin-4-ones and... Novel 2-amino-imidazo[4,5-d]pyridazin-4-ones and...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61K 31/5025 (2006.01) A61P 3/10 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2561210

The invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino- imidazo[4,5-c]pyridin-4-ones of general formula (I), where R1 to R4 and X are as defined in claims 1 to 6, the tautomers, enantiomers, diastereomers, mixtures and salts thereof with useful pharmacological properties, in particular an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

La présente invention concerne des 2-amino-imidazo[4,5-d]pyridazin-4-ones et 2-amino-imidazo[4,5-c]pyridin-4-ones de formule générale (I), dans laquelle R?1¿ à R?4¿ et X sont tels que définis dans les revendications 1 à 6, leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, lesquels composés présentent de précieuses propriétés pharmacologiques, en particulier un effet inhibiteur sur l'activité de l'enzyme dipeptidylpeptidase-IV (DPP-IV).

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