Phenol derivatives with pharmaceutical activity

Details Phenol derivatives with pharmaceutical activity Phenol derivatives with pharmaceutical activity

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2232059

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R is as defined herein, are prodrugs for a competitive N-methyl-D- aspartic acid antagonist which blocks NMDA receptor sites and is useful in the treatment of certain conditions and diseases that respond to the blocking of NMDA receptor sites, including head trauma, stroke, multiinfarct dementia, and other disorders.

Composés de la formule (I) et sels de ces composés acceptables d'un point de vue pharmaceutique, formule dans laquelle R est tel que le définit la description, lesdits composés et sels constituant des promédicaments pour un antagoniste compétitif d'acide N-méthyl D-aspartique (NMDA), qui bloque les sites récepteurs de NMDA et est utile dans le traitement de certains états et certaines maladies réagissant au blocage de sites récepteurs de NMDA, tels que le traumatisme crânien, l'attaque, la démence due à des infarctus multiples, ou d'autres troubles.

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