Stabilized tibolone compositions

Details Stabilized tibolone compositions Stabilized tibolone compositions

A - Human Necessities

61

K

A61K 31/567 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 47/14 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2288070

The invention pertains to a pharmaceutical dosage unit, such as a tablet or a capsule, comprising an effective amount of tibolone (generally of from 0.1 to 10 % by weight) and a starch-containing pharmaceutically acceptable carrier (also denoted as basic granulate), wherein the carrier contains of from 10 to 100 % by weight of the starch. Thus a more stable tibolone formulation is obtained, allowing dry storage and lower doses of active ingredient.

L'invention concerne une unité posologique pharmaceutique, comme un comprimé ou une gélule, comprenant une dose efficace de tibolone (généralement entre 0,1 et 10 % en poids) ainsi qu'un excipient contenant de l'amidon, acceptable sur le plan pharmacologique (également indiqué en tant que granulat de base), lequel excipient contient entre 10 et 100 % en poids d'amidon. De cette manière, on obtient une formulation à base de tibolone, plus stable, permettant une conservation dans une atmosphère sèche, ainsi que des doses moindres de principe actif.

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