Interleukin-8 receptors and related molecules and methods

Details Interleukin-8 receptors and related molecules and methods Interleukin-8 receptors and related molecules and methods

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12Q 1/02 (2006.01) G01N 33/52 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2107682

2107682 9218641 PCTABS00017 Disclosed are cDNAs encoding IL-8 receptors and the recombinant proteins expressed from such cDNAs. The recombinant receptor and receptor fragments and analogs are used in methods of screening candidate compounds for their ability to antagonize interaction between IL-8 and an IL-8 receptor; antagonists are used as therapeutics to reduce inflammation. Antibodies specific for IL-8 receptor (or receptor fragment or analog) and their use as a therapeutic are also disclosed.

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