Antiallergic triazolo(pyrrolo, thieno or furano)azepine...

Details Antiallergic triazolo(pyrrolo, thieno or furano)azepine... Antiallergic triazolo(pyrrolo, thieno or furano)azepine...

C - Chemistry, Metallurgy

07

D

C07D 495/14 (2006.01) A61K 31/55 (2006.01) C07D 487/14 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2150804

Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G- is a bivalent radical of formula -X-C(R1) CH-(a-1); or -CH C(R2)-X- (a-2); X represents O, S or NR3; R3 represents hydrogen, C1-6alkyl or C1-4alkylcarbonyl; -B D- is a bivalent radical of formula -C(R4) N- (b-1); or -N C(R5)- (b-2); L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2) or - Alk-Het3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.

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