Therapy using lymphotoxin and thrombopoietin

Details Therapy using lymphotoxin and thrombopoietin Therapy using lymphotoxin and thrombopoietin

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 45/06 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2220336

Methods and compositions are provided which include use of lymphotoxin ("LT") and one or more other anti-cancer therapies for treating cancer in vivo or ex vivo. LT can be employed, for instance, with chemotherapy or radiation therapy to provide improved anti-cancer therapy. Methods and compositions are also provided which include use of LT and thrombopoietin for enhancing magakaryocyte maturation or thrombocyte production. In one embodiment, the LT and thrombopoietin are used to treat thrombocytopenia in a mammal.

Procédés et compositions comprenant l'utilisation de lymphotoxine ("LT") associée à une ou plusieurs autres thérapeutiques anticancéreuses pour traiter le cancer in vivo ou ex vivo. La LT peut être employée, par exemple, en association avec la chimiothérapie ou la radiothérapie pour donner une thérapie anticancéreuse améliorée. Sont également décrites des méthodes et des compositions comprenant l'utilisation de LT et de thrombopoiétine pour favoriser la maturation des mégacaryocytes ou la production de thrombocytes. Selon un mode de réalisation, le LT et la thrombopoiétine sont utilisées pour traiter la thrombocytopénie chez un mammifère.

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